Aspirin Use for Secondary Prevention Amid Negative Messaging in Patients With Cardiovascular Disease - Summary - MDSpire

Aspirin Use for Secondary Prevention Amid Negative Messaging in Patients With Cardiovascular Disease

  • By

  • Jeremy R. Van’t Hof

  • Sue Duval

  • Niki Oldenburg

  • Milton Eder

  • Russell V. Luepker

  • June 4, 2026

  • 0 min

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Objective:

To investigate changes in aspirin use for secondary prevention between 2015 and 2020, particularly in light of adverse perceptions among cardiovascular disease patients.

Key Findings:
  • 75.5% of participants currently used aspirin, 14.7% never used it, and 9.8% had stopped, indicating a stable use pattern despite negative messaging.
  • Conversations about aspirin with a physician were more common among regular users (64.4%) compared to stoppers (44.1%) and never users (18.1%), highlighting the role of clinician communication.
  • Only 1.8% of aspirin stoppers cited negative messaging as the reason for stopping; 65.9% cited a physician's recommendation, suggesting clinician influence is paramount.
Interpretation:

Despite increasing negative messaging about aspirin for primary prevention, secondary prevention aspirin use remained stable from 2015 to 2020, indicating that clinician guidance may mitigate adverse perceptions.

Limitations:
  • Self-reported data may lead to misclassification, which could affect the reliability of the findings.
  • Regional sampling limits generalizability, and the use of landline telephones may bias toward older, more rural individuals.
Conclusion:

Clinician guidance appears to outweigh media influence on aspirin use, emphasizing the importance of patient-clinician communication in maintaining adherence to evidence-based practices.

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