Coordinated Signaling Pathways in Airway Epithelium Connect Allergen-Induced Inflammation to Structural Changes in Asthma

To synthesize mechanisms linking allergen-induced inflammation to structural changes in asthma, emphasizing the airway epithelium's role.

Mechanistic Analysis: The review analyzes integrated signaling pathways activated in airway epithelial cells upon allergen challenge, including EGFR, MAPK, PI3K/AKT, NF-κB, JAK/STAT, and TGF-β/SMAD.
Endotype Examination: It maps the mechanistic basis of asthma endotype heterogeneity, including eosinophilic and neutrophilic subtypes, to specific signaling network configurations.
Therapeutic Implications: The review discusses therapeutic implications, including approved biologics, kinase inhibitors, and barrier-restoration strategies.

Asthma is marked by chronic inflammation and structural remodeling, with the airway epithelium as a central player.
Allergen exposure activates signaling pathways that lead to acute inflammatory responses and chronic remodeling.
Asthma shows immunological heterogeneity, with different endotypes responding variably to therapies.

The airway epithelium actively regulates immune responses through integrated signaling pathways that contribute to asthma.

The review focuses on signaling pathways and lacks extensive clinical trial data to support therapeutic implications.
It may not cover all potential signaling interactions or emerging therapeutic strategies.

Understanding the signaling networks in airway epithelium is essential for addressing asthma complexities and developing targeted therapies.