Absence of Macrolide-Resistant Mutations in Bordetella pertussis in Antananarivo (Madagascar) and Cambodia During the Last Pertussis Cycle Before the COVID-19 Pandemic - Summary - MDSpire
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Lack of Macrolide-Resistant Bordetella pertussis Mutations Observed in Antananarivo (Madagascar) and Cambodia During the Final Pertussis Cycle Prior to the COVID-19 Outbreak

  • By

  • Florence Campana

  • Mahdi Rajabizadeh

  • Mallorie Hide

  • Gauthier Delvallez

  • Samrach Han

  • Lala Rafetrarivony

  • Bunnet Dim

  • Aina Harimanana

  • Gaelle Noel

  • Mohand Ait-Ahmed

  • Jean-Marc Collard

  • Laurence Borand

  • Nicole Guiso

  • Fabien Taieb

  • September 29, 2025

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Objective:

To investigate the presence of macrolide-resistant Bordetella pertussis (MRBP) mutations in Madagascar and Cambodia before the COVID-19 pandemic, highlighting its significance for global health.

Key Findings:
  • No macrolide-resistant Bordetella pertussis (MRBP) mutations were detected in the analyzed samples from Madagascar and Cambodia, indicating a potential underestimation of resistance.
  • All 55 sequences showed absence of the A2047G mutation.
  • The study's small sample size may limit the detection of MRBP, suggesting the need for larger studies.
Interpretation:

The absence of MRBP in the studied regions suggests low levels of macrolide resistance prior to the COVID-19 pandemic; however, rising antibiotic prescriptions during the pandemic may increase resistance risks, necessitating close monitoring.

Limitations:
  • Small sample size may have reduced the likelihood of detecting MRBP.
  • The study did not include culture methods for further validation.
  • Geographical limitations may affect the generalizability of the findings.
Conclusion:

Strengthening MRBP surveillance and vaccination efforts is crucial to prevent the emergence of resistance, especially in low- and middle-income countries, to safeguard public health.

Original Source(s)

Absence of Macrolide-Resistant Mutations in Bordetella pertussis in Antananarivo (Madagascar) and Cambodia During the Last Pertussis Cycle Before the COVID-19 Pandemic

  • by Florence Campana, Mahdi Rajabizadeh, Mallorie Hide, Gauthier Delvallez, Samrach Han, Lala Rafetrarivony, Bunnet Dim, Aina Harimanana, Gaelle Noel, Mohand Ait-Ahmed, Jean-Marc Collard, Laurence Borand, Nicole Guiso, Fabien Taieb

  • September 29, 2025

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