Associations of FGF23 and Apelin-13 with osteoporosis and diabetic peripheral neuropathy in postmenopausal women with type 2 diabetes mellitus - Summary - MDSpire
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Associations of FGF23 and Apelin-13 with osteoporosis and diabetic peripheral neuropathy in postmenopausal women with type 2 diabetes mellitus
To investigate the correlations of FGF23 and Apelin-13 with osteoporosis and diabetic peripheral neuropathy in postmenopausal women with type 2 diabetes mellitus, and evaluate their predictive value for these conditions.
Key Findings:
25OH-VitD and Apelin-13 were protective factors for higher T-scores (p < 0.05).
PTH, CPT scores, and FGF23 were risk factors for lower T-scores (p < 0.05).
Longer diabetes duration and higher FGF23 were associated with increased OP risk (p < 0.01).
Higher E2 and Apelin-13 were linked to decreased OP risk (p < 0.05).
A combined model showed high predictive performance for OP (AUC = 0.958) and DPN (AUC = 0.926).
Interpretation:
Decreased BMD in postmenopausal T2DM women is associated with bone metabolism disorders and an imbalance of FGF23 and Apelin-13, indicating these factors as potential targets for OP and DPN prevention strategies.
Limitations:
Cross-sectional design limits causal inferences.
Findings require external validation.
Sample size may limit the generalizability of results.
Conclusion:
FGF23 and Apelin-13 may serve as potential targets for future research on OP and DPN prevention and treatment in postmenopausal women with T2DM.
Patients with preoperative vitamin D deficiency had higher postoperative pain scores and opioid use after mastectomy, including more than triple the odds of moderate to severe pain within 24 hours of surgery.
