Hemodynamic evaluation following ductal closure and association with IVH in premature infants born at 22–23weeks gestation - Summary - MDSpire

Hemodynamic evaluation following ductal closure and association with IVH in premature infants born at 22–23weeks gestation

  • By

  • Tomonori Kurimoto

  • Katsuaki Toyoshima

  • Hiroshi Ohashi

  • Jun Shibasaki

  • Tomoyuki Shimokaze

  • Tomoko Saito

  • Kaoru Katsumata

  • Asataro Yara

  • Eiji Hirakawa

  • Takuya Tokuhisa

  • June 12, 2026

  • 0 min

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Objective:

To examine whether early hemodynamic changes within 12 hours after PDA closure were associated with subsequent grade 2–4 intraventricular hemorrhage (IVH) in extremely preterm infants.

Key Findings:
  • Infants with IVH exhibited increased end-systolic wall stress, mean arterial pressure, and heart rate, alongside reduced mean velocity of circumferential fiber shortening specifically within 12 hours after ductal closure.
Interpretation:

Limitations:
  • Retrospective design may introduce biases.
  • Small sample size limits generalizability.
Conclusion:

Original Source(s)

Hemodynamic evaluation following ductal closure and association with IVH in premature infants born at 22–23weeks gestation

  • by Tomonori Kurimoto, Katsuaki Toyoshima, Hiroshi Ohashi, Jun Shibasaki, Tomoyuki Shimokaze, Tomoko Saito, Kaoru Katsumata, Asataro Yara, Eiji Hirakawa, Takuya Tokuhisa

  • June 12, 2026

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