Objective:

To report a case of BCOR–CCNB3 fusion-positive sarcoma (BCS) treated with chemotherapy and carbon-ion radiotherapy (CIRT), highlighting long-term disease control and the first reported use of CIRT for this condition.

Approach:

Key Findings:

• The patient achieved complete response (CR) after treatment.
• No neurological deficits or tumor recurrence were observed over 12 years.
• Cervical kyphosis was noted radiographically.
• Genetic analysis confirmed the presence of the BCOR–CCNB3 fusion gene.

Interpretation:

This case suggests that CIRT may be a promising treatment option for BCS when surgical resection is challenging, marking a significant advancement in treatment options.

Limitations:

• The rarity of BCS limits the generalizability of findings.
• Long-term outcomes for BCS involving the spine are not well documented, and specific studies on CIRT for BCS are lacking.

Conclusion:

CIRT combined with chemotherapy may provide durable local control in BCS, as demonstrated in this case.

Source

Based on findings from:

BCOR-CCNB3 fusion–positive sarcoma treated with chemotherapy and carbon-ion radiotherapy: a case report of long-term disease control of a cervical spine case with a 12-year follow-up

Naoki Oike, Reiko Imai, Akira Ogose, Takashi Ariizumi, Yudai Murayama, Tomohiro Miyazaki, Kazunaga Kimura, Hajime Umezu, Hiroyuki Kawashima. Frontiers In Oncology, 2026.

https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1869278/full

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