Objective:

To report a case of BCOR–CCNB3 fusion-positive sarcoma (BCS) treated with chemotherapy and carbon-ion radiotherapy (CIRT), highlighting long-term disease control and the first reported use of CIRT for this condition.

Approach:

Key Findings:

• The patient achieved complete response (CR) after treatment.
• No neurological deficits or tumor recurrence were observed over 12 years.
• Cervical kyphosis was noted radiographically.
• Genetic analysis confirmed the presence of the BCOR–CCNB3 fusion gene.

Interpretation:

This case suggests that CIRT may be a promising treatment option for BCS when surgical resection is challenging, marking a significant advancement in treatment options.

Limitations:

• The rarity of BCS limits the generalizability of findings.
• Long-term outcomes for BCS involving the spine are not well documented, and specific studies on CIRT for BCS are lacking.

Conclusion:

CIRT combined with chemotherapy may provide durable local control in BCS, as demonstrated in this case.

Attribution Notice

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