Percutaneous endoscopic interlaminar discectomy vs. percutaneous endoscopic transforaminal discectomy for L5/S1 lumbar disc herniation: a systematic review and meta-analysis of randomized controlled trials - Summary - MDSpire

Percutaneous endoscopic interlaminar discectomy vs. percutaneous endoscopic transforaminal discectomy for L5/S1 lumbar disc herniation: a systematic review and meta-analysis of randomized controlled trials

  • By

  • Huatao Chen

  • Cai Cheng

  • July 14, 2026

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Objective:

To compare the perioperative efficiency, clinical outcomes, and safety of percutaneous endoscopic interlaminar discectomy (PEID) and percutaneous endoscopic transforaminal discectomy (PETD) for single-level L5/S1 lumbar disc herniation (LDH).

Approach:
  • Eligibility Criteria: Included randomized controlled trials comparing PEID and PETD for single-level L5/S1 LDH.
Key Findings:
  • PEID was associated with shorter operative time compared to PETD (MD = -17.07 min).
  • Fluoroscopy frequency favored PEID (MD = -8.94 counts).
  • No significant difference in hospital stay (MD = 0.38 days).
  • VAS leg pain and ODI outcomes were comparable across follow-up time points.
  • Complications/adverse events did not differ significantly between the two approaches.
Interpretation:

PEID may offer advantages in operative time and fluoroscopy frequency, but the clinical outcomes and safety profiles are broadly comparable to PETD.

Limitations:
  • High between-study heterogeneity in several outcomes.
  • Geographic concentration of studies.
  • Methodological limitations in the included studies.
Conclusion:

Findings should be interpreted cautiously, and procedure selection should remain individualized.

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