Epidemiology, determinants, and microbiological profile of implant-associated infections following intramedullary nailing in a tertiary hospital in Ethiopia - Summary - MDSpire
To quantify implant-associated infections after femoral or tibial intramedullary nailing at a tertiary hospital in Ethiopia, assess associated patient, injury, and perioperative factors, and describe pathogens and antimicrobial resistance patterns.
Approach:
Design and setting: Hospital-based cross-sectional investigation at the University of Gondar Comprehensive Specialized Hospital.
Population: Patients undergoing femoral or tibial intramedullary nailing from January 2021 through December 2023.
Analysis sample: Of 295 identified patients, 260 were included after exclusions for pathological fractures, surgery at another institution, or incomplete registry data.
Outcome and variables: The primary outcome was surgeon-documented implant-associated infection using Metsemakers et al. criteria. Collected variables covered sociodemographic, clinical, injury, and perioperative characteristics.
Antibiotic prophylaxis: Routine prophylaxis followed the Ethiopian Standard Treatment Guideline, with regimens varying by fracture type and severity.
Interpretation:
The provided context describes the study rationale and methods but does not report results.
Limitations:
Twenty-nine patients were excluded because of incomplete data registry.
The supplied context does not include study results or details of microbiological testing and susceptibility methods.
Machine-learning models distinguished healthy knees from those with osteoarthritis-related cartilage damage, but age and BMI performed as well as or better than the vibration-based models.
