Intraoperative Lidocaine Infusion Therapy and Neurophysiological Monitoring in Adolescents Undergoing Idiopathic Scoliosis Correction: A Supplemental Analysis of a Prospective Study - Summary - MDSpire
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Evaluation of Intraoperative Lidocaine Administration and Neurophysiological Monitoring in Adolescents Undergoing Surgery for Idiopathic Scoliosis: An Additional Analysis of a Prospective Study
To investigate the effects of intravenous lidocaine infusion therapy (IVLT) on intraoperative neurophysiological monitoring (IONM) during posterior spinal instrumentation and fusion (PSIF) in adolescents.
Approach:
Study Design: A prospective randomized controlled trial involving 44 adolescents aged 10–19 years undergoing PSIF.
Intervention: Participants in the IVLT group received a lidocaine bolus and infusion, while control participants received a placebo.
Data Collection: Intraoperative data included neurophysiological measurements and reportable IONM events.
Statistical Analysis: Data were analyzed using linear mixed-effects modeling.
Key Findings:
No significant difference in reportable IONM events between IVLT (35%) and control (33%) groups.
No evidence of detrimental effects of IVLT on motor and somatosensory evoked potential amplitudes.
Interpretation:
Under controlled conditions, a standardized regime of IVLT did not impact IONM in adolescents undergoing PSIF for idiopathic scoliosis.
Limitations:
Further research is needed to corroborate findings.
The study was limited to a specific patient population and surgical procedure.
Conclusion:
This study confirms that IVLT does not negatively affect IONM during PSIF surgery.
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