To systematically summarize the mechanisms of metabolic reprogramming in oocyte growth and development, focusing on glucose, lipid, and amino acid metabolism, and analyze the association between metabolic abnormalities and reproductive diseases.
Key Findings:
Metabolic dysregulation impairs oocyte quality and embryonic development potential.
Diseases such as diabetes, obesity, and polycystic ovary syndrome disrupt ovarian microenvironmental homeostasis.
Targeted metabolic interventions and optimization of mitochondrial function may improve assisted reproduction success rates, particularly in patients with metabolic disorders.
Interpretation:
Metabolic reprogramming is crucial for oocyte maturation and quality, with significant implications for enhancing reproductive health and the efficacy of assisted reproductive technologies.
Limitations:
The review is based on existing literature, which may not cover all recent findings, particularly emerging studies in metabolic regulation.
Potential biases in the selected studies could affect the conclusions drawn, including publication bias and study design limitations.
Conclusion:
Understanding metabolic reprogramming can provide insights into improving oocyte quality and reproductive outcomes, highlighting the need for further research in metabolic regulation, particularly in the context of assisted reproductive technologies.
