To investigate the association between central sensitization and multisystemic symptom burden in patients with hEDS/HSD and identify independent clinical predictors of CS.
Approach:
Study Design: A prospective observational study enrolling 150 adults diagnosed with hEDS/HSD at a specialized clinic, utilizing the Central Sensitization Inventory (CSI) and SPIDER questionnaire.
Statistical Analysis: Univariate correlations and multivariable logistic regression were performed to analyze the data.
Key Findings:
Centrally sensitized patients (n = 76) were significantly younger and predominantly female compared to the non-CS group (n = 74).
CSI scores correlated strongly with all eight SPIDER domains (p < 0.001).
Three independent predictors of CS identified were fatigue (OR 1.089), pain (OR 1.067), and cardiac dysautonomia (OR 1.057).
Interpretation:
Central sensitization in hEDS/HSD is independently associated with a triad of fatigue, pain, and cardiac dysautonomia.
Limitations:
The study was conducted at a single specialized clinic, which may limit generalizability.
The reliance on self-reported measures may introduce bias.
Conclusion:
Clinical management should shift toward multidisciplinary strategies to effectively address the sensitized state in this population.
by Ana Paula Montemayor Zarazúa, César Vidal Elizondo Solis, Camila Ayala García, Diego Jesús Pacheco Estrella, Octavio Ilizaliturri Guerra, Ana Cecilia Arana Guajardo, Emma Purón Gonzalez, Karina Silva Luna, Luis Iván Lozano Plata, Mario Ramon García Pompermayer, Mario Alberto Garza Elizondo
