Pulsed field ablation vs. medical therapy for atrial fibrillation: a propensity score–matched comparison with the JoFib registry - Summary - MDSpire

Pulsed field ablation vs. medical therapy for atrial fibrillation: a propensity score–matched comparison with the JoFib registry

  • By

  • Abdalrahman Al-slaimieh

  • Khaled A. Abukhalaf

  • Nour S. Haj Ali

  • Jude Awad

  • Abdallah Al-Ani

  • Ayman J. Hammoudeh

  • Mohammad Hajjiri

  • June 5, 2026

  • 0 min

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Objective:

To compare the efficacy of pulsed field ablation (PFA) versus medical therapy alone for the treatment of atrial fibrillation (AF), highlighting the significance of this comparison in clinical practice.

Key Findings:
  • PFA showed significantly lower readmission rates at 1 month (3.2% vs. 12.9%) and 6 months (4.8% vs. 17.7%) compared to medical therapy (p < 0.05), analyzed using appropriate statistical methods.
  • Kaplan–Meier analysis indicated higher freedom from readmission rates in the PFA cohort (92% vs. 69%; log-rank p = 0.002).
Interpretation:

The findings support the efficacy of PFA as a treatment for AF, aligning with global consensus and existing literature on the subject.

Limitations:
  • The study is retrospective and based on a single-center experience, which may introduce biases.
  • The sample size is relatively small, limiting generalizability.
Conclusion:

This early report from the MENA region lays the foundation for future larger studies to investigate PFA in this specific population, emphasizing the need for further validation.

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