Ferroptosis, Pyroptosis, and Necroptosis in Melanoma: Regulatory Cell Death Pathways and Their Implications for Immunotherapy
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By
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Wang, Qingyi
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Zhu, Jian
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April 2, 2026
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Objective:
To summarize the roles of ferroptosis, pyroptosis, and necroptosis in melanoma and their potential to enhance immunotherapy.
Key Findings:
- Ferroptosis, pyroptosis, and necroptosis can remodel the tumor immune microenvironment.
- These regulated cell death pathways enhance tumor immunogenicity.
- Targeting these pathways may overcome limitations of current melanoma immunotherapies.
Interpretation:
The review highlights the potential of regulated cell death pathways as therapeutic targets to improve melanoma treatment outcomes.
Limitations:
- Current understanding of RCD pathways in melanoma is still evolving.
- Clinical translation of these findings requires further research and validation.
Conclusion:
Inducing ferroptosis, pyroptosis, and necroptosis may provide new strategies to enhance the efficacy of melanoma immunotherapy.
