Research progress on debridement, antibiotics, and implant retention (DAIR) for the treatment of periprosthetic joint infection after artificial joint replacement - Summary - MDSpire
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Advancements in Debridement, Antibiotic Therapy, and Implant Preservation (DAIR) for Managing Periprosthetic Joint Infections Following Joint Replacement Surgery

  • By

  • Wenguang Feng

  • Zhichao Zhang

  • Ribusurong Pu

  • Haibin Wang

  • Rui Liu

  • Yanhong Sun

  • Guoliang Zhang

  • July 3, 2026

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Objective:

To evaluate the indications, influencing factors, and technical advancements of DAIR to improve treatment success rates.

Approach:
  • Timing of Debridement: DAIR is recommended for acute postoperative PJI and acute hematogenous PJI, ideally performed within 4 weeks of symptom onset.
Key Findings:
  • DAIR success rates exceed 80% when performed within 90 days of surgery.
  • Delays beyond one month significantly reduce DAIR success rates.
  • Obesity, diabetes, and immunosuppression are critical risk factors for PJI.
Interpretation:

Early diagnosis and timely intervention are crucial for maximizing the effectiveness of DAIR.

Limitations:
  • Real-world effectiveness of DAIR may be lower than reported success rates from specialized centers.
Conclusion:

DAIR is a time-sensitive treatment that can preserve implants and improve patient outcomes when applied early and with consideration of patient-specific factors.

Original Source(s)

Research progress on debridement, antibiotics, and implant retention (DAIR) for the treatment of periprosthetic joint infection after artificial joint replacement

  • by Wenguang Feng, Zhichao Zhang, Ribusurong Pu, Haibin Wang, Rui Liu, Yanhong Sun, Guoliang Zhang

  • July 3, 2026

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