Objective:

To report a rare case of overlapping features of Behçet’s uveitis and multizonal outer retinopathy and retinal pigment epitheliopathy (MORR), documented by longitudinal multimodal imaging, highlighting the clinical significance of these findings.

Key Findings:

• The patient exhibited bilateral, progressive outer retinopathy concurrent with retinal vasculitis, indicating a complex interaction between the two conditions.
• Multimodal imaging revealed features consistent with both Behçet-associated retinal vasculitis and MORR, underscoring the need for careful diagnostic evaluation.
• The patient responded favorably to systemic treatment with oral corticosteroids and cyclosporine, suggesting a potential therapeutic strategy for similar cases.

Interpretation:

This case highlights the potential association between Behçet’s disease and MORR, emphasizing the need for multimodal imaging in diagnosis and the importance of recognizing concurrent outer retinopathy in clinical practice.

Limitations:

• This is a single case report, limiting generalizability and necessitating further studies to validate findings.
• Longitudinal follow-up was limited to 9 months, which may not capture the full progression of the disease.

Conclusion:

The findings suggest a complex interplay between Behçet’s disease and MORR, warranting further investigation into their relationship and potential shared pathophysiological mechanisms.