Risk Factors for the Development of Food Allergy in Infants and Children: A Systematic Review and - Summary - MDSpire

Risk Factors for the Development of Food Allergy in Infants and Children: A Systematic Review and

  • By

  • Nazmul Islam

  • Alexandro W. L. Chu

  • Falana Sheriff

  • Farid Foroutan

  • Gordon H. Guyatt

  • Romina Brignardello-Petersen

  • Paul Oykhman

  • Alfonso Iorio

  • Ariel Izcovich

  • Katherine M. Morrison

  • Yetiani Roldan Benitez

  • Rachel J. Couban

  • Dorota Borovsky

  • Yiming Zhang

  • Leonardo Ologundudu

  • Keerthana Pasumarthi

  • Syed Fahad Farooq

  • Kyle Tong

  • Wang-Choi Tang

  • Haseeb Faisal

  • Muhammad Faran Khalid

  • Mohammad Saad Asif

  • Shannon French

  • Susan Waserman

  • R. Sharon Chinthrajah

  • Hugh A. Sampson

  • S. Shahzad Mustafa

  • Jay A. Lieberman

  • Kirsi M. Järvinen

  • Sally Bailey

  • Philippe Bégin

  • Scott H. Sicherer

  • Jennifer Gerdts

  • Melanie Carver

  • Lynda Mitchell

  • Kelly Cleary

  • Matthew J. Greenhawt

  • Julie Wang

  • Aikaterini Anagnostou

  • Marcus S. Shaker

  • Anita Chandra-Puri

  • Patricia C. Fulkerson

  • Robert A. Wood

  • Derek K. Chu

  • May 1, 2026

  • 0 min

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Objective:

To systematically review and synthesize the incidence of and risk factors for the development of IgE-mediated food allergy in infants and children, emphasizing the systematic nature of the review.

Key Findings:
  • Food allergy is a significant health burden, affecting over 33 million people in the US.
  • IgE-mediated food allergies often develop early in life and can lead to anaphylaxis.
  • There is a lack of consensus on at-risk populations and modifiable factors for prevention, with specific data indicating a rising trend.
Interpretation:

The review highlights the urgent need for evidence-based strategies to identify and prevent food allergies, given the rising incidence and unclear risk factors, with implications for clinical practice.

Limitations:
  • Uncertainty in identifying clear risk factors for food allergy development, including potential biases in the studies reviewed.
  • Exclusion of studies addressing posttransplant populations or alpha-gal food allergy.
Conclusion:

This comprehensive review underscores the complexity of food allergy development and the necessity for targeted prevention strategies, highlighting the importance of addressing identified research gaps.

Original Source(s)

Risk Factors for the Development of Food Allergy in Infants and Children: A Systematic Review and

  • by Nazmul Islam, Alexandro W. L. Chu, Falana Sheriff, Farid Foroutan, Gordon H. Guyatt, Romina Brignardello-Petersen, Paul Oykhman, Alfonso Iorio, Ariel Izcovich, Katherine M. Morrison, Yetiani Roldan Benitez, Rachel J. Couban, Dorota Borovsky, Yiming Zhang, Leonardo Ologundudu, Keerthana Pasumarthi, Syed Fahad Farooq, Kyle Tong, Wang-Choi Tang, Haseeb Faisal, Muhammad Faran Khalid, Mohammad Saad Asif, Shannon French, Susan Waserman, R. Sharon Chinthrajah, Hugh A. Sampson, S. Shahzad Mustafa, Jay A. Lieberman, Kirsi M. Järvinen, Sally Bailey, Philippe Bégin, Scott H. Sicherer, Jennifer Gerdts, Melanie Carver, Lynda Mitchell, Kelly Cleary, Matthew J. Greenhawt, Julie Wang, Aikaterini Anagnostou, Marcus S. Shaker, Anita Chandra-Puri, Patricia C. Fulkerson, Robert A. Wood, Derek K. Chu

  • May 1, 2026

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