Immunogenicity and Reactogenicity of High- or Standard-Dose Influenza Vaccine in a Second Consecutive Influenza Season - Summary - MDSpire

Immunogenicity and Reactogenicity of High- or Standard-Dose Influenza Vaccine in a Second Consecutive Influenza Season

  • By

  • Hannah Bahakel

  • Andrew J Spieker

  • Haya Hayek

  • Jennifer E Schuster

  • Lubna Hamdan

  • Daniel E Dulek

  • Carrie L Kitko

  • Tess Stopczynski

  • Einas Batarseh

  • Zaid Haddadin

  • Laura S Stewart

  • Anna Stahl

  • Molly Potter

  • Herdi Rahman

  • Justin Amarin

  • Spyros A Kalams

  • Claire E Bocchini

  • Elizabeth A Moulton

  • Susan E Coffin

  • Monica I Ardura

  • Rachel L Wattier

  • Gabriela Maron

  • Michael Grimley

  • Grant Paulsen

  • Christopher J Harrison

  • Jason Freedman

  • Paul A Carpenter

  • Janet A Englund

  • Flor M Munoz

  • Lara Danziger-Isakov

  • Natasha Halasa

  • for the Pediatric HCT Flu Study

  • Rakesh Goyal

  • Rendie McHenry

  • Margaret Bender

  • Shari Barto

  • Michael Russo

  • Lauren Shoemaker

  • Kenny Truong

  • Christopher Dvorak

  • Kim J Allison

  • Swati Naik

  • Christopher Williams

  • Samantha Blum

  • Kirsten Lacombe

  • Hannah Smith

  • September 16, 2024

  • 0 min

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Objective:

To evaluate the immunogenicity and safety of high-dose trivalent influenza vaccine (HD-TIV) compared to standard-dose quadrivalent influenza vaccine (SD-QIV) in pediatric hematopoietic cell transplant (HCT) recipients during a consecutive influenza season.

Key Findings:
  • Post-vaccine geometric mean fold rise in hemagglutinin inhibition titers was higher for both groups in year 2 compared to year 1.
  • One dose of either HD-TIV or SD-QIV was more immunogenic in year 2 than two doses in year 1.
  • Reactogenicity was comparable between HD-TIV and SD-QIV groups.
Interpretation:

A single dose of influenza vaccine may be sufficient for pediatric HCT recipients after a prior two-dose schedule, indicating potential for reduced vaccination burden.

Limitations:
  • The study was limited to a specific population of pediatric HCT recipients, which may affect generalizability.
  • The sample size was relatively small, potentially limiting the statistical power of the findings.
Conclusion:

The findings suggest that a single dose of influenza vaccine can provide adequate immunogenicity in pediatric HCT recipients following a two-dose regimen in the previous season.

Original Source(s)

Immunogenicity and Reactogenicity of High- or Standard-Dose Influenza Vaccine in a Second Consecutive Influenza Season

  • by Hannah Bahakel, Andrew J Spieker, Haya Hayek, Jennifer E Schuster, Lubna Hamdan, Daniel E Dulek, Carrie L Kitko, Tess Stopczynski, Einas Batarseh, Zaid Haddadin, Laura S Stewart, Anna Stahl, Molly Potter, Herdi Rahman, Justin Amarin, Spyros A Kalams, Claire E Bocchini, Elizabeth A Moulton, Susan E Coffin, Monica I Ardura, Rachel L Wattier, Gabriela Maron, Michael Grimley, Grant Paulsen, Christopher J Harrison, Jason Freedman, Paul A Carpenter, Janet A Englund, Flor M Munoz, Lara Danziger-Isakov, Natasha Halasa, for the Pediatric HCT Flu Study, Rakesh Goyal, Rendie McHenry, Margaret Bender, Shari Barto, Michael Russo, Lauren Shoemaker, Kenny Truong, Christopher Dvorak, Kim J Allison, Swati Naik, Christopher Williams, Samantha Blum, Kirsten Lacombe, Hannah Smith

  • September 16, 2024

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