A review of the pathogenic mechanism and clinical management progress of in-stent calcification restenosis
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By
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Xiangchen Xia
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Fei Luo
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Jianchun Li
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Quanyi Liu
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Jianzhong Pang
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Fuyun Jia
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Qiang Xu
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Chao Peng
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May 29, 2026
Objective:
To summarize the pathophysiological mechanisms, imaging evaluation, and advances in the clinical management of coronary in-stent calcific restenosis.
Key Findings:
- Calcification restricts stent expansion and exacerbates neointimal hyperplasia and neoatherosclerosis, increasing ISR risk.
- High-resolution imaging techniques provide insights into calcification morphology and its impact on restenosis.
- Novel therapies have improved the management of calcific ISR.
Interpretation:
Limitations:
- The review does not provide specific clinical trial data to support the efficacy of the novel therapies discussed.
- Future research directions are proposed but not detailed.
Conclusion:
The article synthesizes current knowledge on calcific ISR.
