Fetal malformations of cortical development: review and clinical guidance - Summary - MDSpire

Fetal malformations of cortical development: review and clinical guidance

  • By

  • Jeffrey B Russ

  • Sonika Agarwal

  • Charu Venkatesan

  • Barbara Scelsa

  • Brigitte Vollmer

  • Tomo Tarui

  • Andrea C Pardo

  • Monica E Lemmon

  • Sarah B Mulkey

  • Anthony R Hart

  • Usha D Nagaraj

  • Jeffrey A Kuller

  • Matthew T Whitehead

  • Jennifer L Cohen

  • Juliana S Gebb

  • Orit A Glenn

  • Mary E Norton

  • Dawn Gano

  • March 6, 2025

  • 0 min

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Objective:

To review the literature on fetal malformations of cortical development (MCDs) and present practice guidelines for clinicians regarding both pre- and postnatal management, emphasizing their distinct approaches.

Key Findings:
  • MCDs are a heterogeneous group of congenital brain malformations with significant long-term morbidity, impacting clinical decision-making.
  • Advances in antenatal genetic testing and imaging have improved prenatal diagnosis of MCDs, enhancing early intervention opportunities.
  • There is limited literature on prognostication and perinatal management of MCDs, highlighting a need for further research.
Interpretation:

The variability in MCD types and outcomes complicates prenatal counseling, necessitating a careful balance between conveying the seriousness of the condition and the inherent uncertainties of outcomes.

Limitations:
  • Limited data on the prenatal evolution of MCDs across gestational ages, particularly regarding specific developmental milestones.
  • Insufficient detailed outcomes data for clinicians to provide accurate prognoses, especially concerning long-term developmental trajectories.
Conclusion:

Improved understanding of cortical development and MCDs is essential for enhancing prenatal care and counseling for affected families, ultimately guiding better clinical practices.

Original Source(s)

Fetal malformations of cortical development: review and clinical guidance

  • by Jeffrey B Russ, Sonika Agarwal, Charu Venkatesan, Barbara Scelsa, Brigitte Vollmer, Tomo Tarui, Andrea C Pardo, Monica E Lemmon, Sarah B Mulkey, Anthony R Hart, Usha D Nagaraj, Jeffrey A Kuller, Matthew T Whitehead, Jennifer L Cohen, Juliana S Gebb, Orit A Glenn, Mary E Norton, Dawn Gano

  • March 6, 2025

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