To examine the phenotypic and functional remodeling of the peripheral nervous system within the tumor microenvironment and explore neuro-immune crosstalk mechanisms, highlighting their significance in cancer progression.
Key Findings:
The nervous system significantly influences tumor initiation, progression, and metastasis, suggesting new therapeutic targets.
Tumors can hijack neural structures to promote their own growth and survival, indicating a need for targeted interventions.
Enhanced axonogenesis in the tumor microenvironment is correlated with tumor progression, highlighting a potential area for therapeutic exploration.
Neurotrophins like NGF and BDNF play crucial roles in axonogenesis and tumor-supporting activities, suggesting their targeting could improve treatment efficacy.
Interpretation:
The neuro-immune axis represents a critical area for developing targeted therapies to overcome immunotherapy resistance in cancer treatment, necessitating further research.
Limitations:
Current understanding of neuro-immune interactions and their molecular mechanisms is still limited, which may hinder the development of effective therapies.
The review primarily focuses on peripheral nervous system remodeling, potentially overlooking central nervous system interactions that could also be relevant.
Conclusion:
Targeting neuro-immune interactions could provide novel therapeutic avenues for cancer treatment, emphasizing the need for integrated strategies to address current treatment challenges.
