Electroacupuncture alleviates myocardial ischemia-reperfusion injury by targeting and inhibiting NLRP3 inflammasome-mediated cardiomyocyte pyroptosis via serum exosomal miR-22-3p

By
Jian Xiong
Ying Wei
Yunnan Liu
Fayang Ling
Yi Zhao
Yu Liu
Yuxin Sun
Dehua Li
Mingsheng Sun
Dingjun Cai
Wenchuan Qi
Qianhua Zheng
Fanrong Liang
June 1, 2026
0 min

Frontiers In Immunology

Objective:

To explore the protective effects and molecular mechanisms of electroacupuncture (EA) targeting NLRP3 inflammasome-mediated myocardial cell death in myocardial ischemia-reperfusion injury (MIRI), focusing on serum exosomes.

Key Findings:

EA alleviates MIRI by targeting and inhibiting NLRP3-mediated myocardial apoptosis.
miR-22-3p is upregulated in serum exosomes following EA treatment.
Exosomes from serum samples of AMI-PCI patients and MIRI model rats were isolated and analyzed.

Interpretation:

The study indicates that miR-22-3p is upregulated in serum exosomes following EA treatment.

Limitations:

Conclusion:

The study provides evidence that EA can be a therapeutic strategy for reducing myocardial injury in MIRI through modulation of exosomal miR-22-3p.

Electroacupuncture alleviates myocardial ischemia-reperfusion injury by targeting and inhibiting NLRP3 inflammasome-mediated cardiomyocyte pyroptosis via serum exosomal miR-22-3p

Objective:

Key Findings:

Interpretation:

Limitations:

Conclusion:

Original Source(s)

Electroacupuncture alleviates myocardial ischemia-reperfusion injury by targeting and inhibiting NLRP3 inflammasome-mediated cardiomyocyte pyroptosis via serum exosomal miR-22-3p

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