Objective:

The article examines the objective, findings, and clinical context described in Retraction and Replacement Notice: Ekwunife O et al. on Social Risk Factors and Disparities in Advanced Cardiovascular-Kidney-Metabolic Syndrome.

Approach:

• Risk threshold correction: The code applied 0.2 to PREVENT risk values expressed on a 0%–100% scale, rather than the intended threshold of 20%. The corrected code uses 20% for CKM stage 3 high 10-year cardiovascular disease risk.
• Anthropometric classification correction: The original code accepted either normal BMI or normal waist circumference for CKM stage 0; the corrected definition requires both measures to be within the normal range.
• Reanalysis: The authors reran cohort classification, descriptive and regression analyses, subgroup and interaction models, and related tables and narrative results using both corrected definitions.

Key Findings:

• The corrected cohort included 28,184 participants: 22,305 classified as nonadvanced and 5,879 as advanced CKM syndrome. Thirty-four participants without CKM stage data were excluded.
• Corrected survey-weighted prevalence of advanced CKM syndrome was 15.8%, representing an estimated 26,132,788 US adults among a survey-weighted total of 165,637,840.
• The authors reported that the principal interpretation remained: advanced CKM syndrome was associated with several social risk factors, with associations varying across racial and ethnic groups and between sexes.
• In the main article, statistical-significance classification changed for 31 findings; 98 other estimates changed in magnitude or confidence interval while retaining their original significance classification. In interaction models, 14 findings changed significance classification, while 61 estimates changed without changing classification.
• Age interactions were significant for economic stability, neighborhood or built environment, and social or community context; education access and health care access showed no significant age interactions.

Interpretation:

The authors stated that the corrected results continued to support the study’s principal interpretation, while selected secondary and subgroup interpretations were revised. They reported that associations were generally stronger among female participants, except for poor neighborhood or built environment.

Limitations:

• The notice describes coding errors in the original analysis that substantially overestimated the descriptive burden of advanced CKM syndrome.
• The supplied notice does not provide the full corrected article, detailed estimates, or the complete revised subgroup results.

Conclusion:

The authors requested retraction and replacement of the original article with a corrected version after identifying and correcting the classification errors. They reported that a complete rerun and reconciliation found no further errors.

Sources:

• Retraction and Replacement Notice (source text supplied in the prompt; URL not provided)