Correction: Infection risk reduction with povidone-iodine rectal disinfection prior to transrectal prostate biopsy: an updated systematic review and meta-analysis - Summary - MDSpire
Advertisement
Correction: Infection risk reduction with povidone-iodine rectal disinfection prior to transrectal prostate biopsy: an updated systematic review and meta-analysis
To summarize available data and compare the efficacy of rectal disinfection using povidone-iodine (PI) with non-PI methods, including antibiotic prophylaxis (AP), prior to transrectal ultrasound-guided prostate biopsy (TRUS-PB).
Key Findings:
Overall rates of infectious complications were significantly lower with PI disinfection (RR 0.58, 95% CI 0.43–0.76, p < 0.001).
Combination of antibiotic prophylaxis (AP) and PI significantly reduced risk of infectious complications (RR 0.47, 95% CI 0.30–0.73, p = 0.001) and fever (RR 0.47, 95% CI 0.30–0.75, p = 0.001).
No significant impact on sepsis rates was observed (RR 0.49, 95% CI 0.23–1.04, p = 0.06).
Fluoroquinolone antibiotics were associated with lower risk of infectious complications and fever compared to non-FQ antibiotics.
Interpretation:
Rectal disinfection with PI significantly reduces infectious complications and fever in patients undergoing TRUS-PB, but does not significantly affect sepsis rates, leaving some uncertainty regarding its effectiveness in this area.
Limitations:
The effectiveness of PI in reducing sepsis remains uncertain.
Variability in antibiotic types and dosages among studies may affect outcomes, potentially skewing results.
Conclusion:
Rectal disinfection with PI is effective in reducing infectious complications and fever in TRUS-PB, but does not significantly reduce sepsis rates.
