Objective:

To evaluate the associations and diagnostic ability of non-traditional lipid parameters and lipid-inflammation parameters with abnormal glucose metabolism, and to investigate the mediating role of high-sensitivity C-reactive protein (hs-CRP).

Approach:

• Study Design: Cross-sectional survey data from 9,790 adults in Fujian Province, China (2020-2021) were analyzed, with 2,301 participants included in the final analysis.

Key Findings:

• All parameters were significantly positively associated with impaired glucose metabolism.
• Several parameters showed nonlinear dose-response relationships.
• In prediabetes, atherogenic coefficient, Castelli’s index-I, remnant cholesterol-CRP index, and RC/HDL-C-CRP had superior diagnostic ability.
• In diabetes, atherogenic index of plasma and RC/HDL-C-CRP performed better.
• hs-CRP partially mediated the association between non-traditional lipid parameters and prediabetes.

Interpretation:

Non-traditional lipid parameters and lipid-inflammation parameters were significantly associated with impaired glucose metabolism, suggesting that incorporating inflammatory information may enhance identification of high-risk individuals.

Limitations:

• The study is cross-sectional, limiting causal inferences.
• Findings may not be generalizable beyond the Chinese adult population.

Conclusion:

Incorporating inflammatory information may enhance the identification of high-risk individuals, particularly in prediabetic populations.