To evaluate the association between the admission NT-proBNP/ALB ratio and the occurrence of in-hospital pericardial effusion (PE) in young adults with acute myocardial infarction (AMI).
Approach:
Study Design: A retrospective observational study conducted at a single center involving 1,974 young AMI patients admitted between January 2018 and October 2025.
Key Findings:
In-hospital PE occurred in 7.1% of the cohort (141/1,974).
The NT-proBNP/ALB ratio (adjusted OR: 3.23, 95% CI: 1.30–5.78, P < 0.001) and Plateletcrit (adjusted OR: 1.87, 95% CI: 1.08–3.23, P = 0.025) were identified as independent risk factors for PE.
Incorporating the NT-proBNP/ALB ratio and Plateletcrit into a clinical model improved the AUC from 0.718 to 0.849 (P < 0.001).
Reclassification analyses showed significant improvements in risk stratification with a categorical NRI of 0.2198 (P < 0.001) and an IDI of 0.1116 (P < 0.001).
Interpretation:
The NT-proBNP/ALB ratio and Plateletcrit provide incremental value for early risk stratification of in-hospital PE in young AMI patients beyond conventional clinical indicators.
Limitations:
The study is retrospective and conducted at a single center, which may limit generalizability.
Potential confounding factors not accounted for in the analysis.
Conclusion:
The admission NT-proBNP/ALB ratio and Plateletcrit are independently associated with in-hospital pericardial effusion in young AMI patients.
