Single-Cell and Plasma Proteomics Do Not Differentiate Patients With and Without SARS-CoV-2 Antigenemia in Convalescence in a Cohort of 100 Patients - Summary - MDSpire
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Single-Cell and Plasma Proteomics Do Not Differentiate Patients With and Without SARS-CoV-2 Antigenemia in Convalescence in a Cohort of 100 Patients
To investigate the association between SARS-CoV-2 antigen persistence in plasma and the risk of developing Long COVID (LC) symptoms, specifically examining whether detectable antigens correlate with the severity or presence of LC symptoms.
Key Findings:
18% of patients had detectable antigens at 3 months; 14% at 12 months, with no significant differences in detection rates between patients with LC symptoms and those fully recovered.
Antigenemia was present in 26.9% of individuals at either time point, indicating a lack of correlation with LC symptoms.
Lower antigen detection rates were observed in hospitalized patients at 3 months.
Interpretation:
The study found no distinct immune profiles or significant differences in plasma proteins between antigenemic and non-antigenemic patients, suggesting that antigen persistence does not correlate with LC symptoms, which may guide future research directions.
Limitations:
Small sample size may limit generalizability.
Lack of vaccination prior to the 3-month assessment could influence results and the interpretation of antigenemia.
Conclusion:
The findings indicate that SARS-CoV-2 antigenemia does not serve as a reliable biomarker for distinguishing between patients with and without Long COVID during convalescence.
A global systematic review of 173 studies found differing associations between COVID-19 infection and vaccination and retinal vascular events, with retinal artery occlusion more common after infection and retinal vein occlusion more common after vaccination.
