Case Report: A four-stage diagnostic cascade: from coronary stents to pancreatic cancer in a patient with recurrent chest pain - Summary - MDSpire

Case Report: A four-stage diagnostic cascade: from coronary stents to pancreatic cancer in a patient with recurrent chest pain

  • By

  • Tao Lin

  • Ziyi Huang

  • Xiahui Huang

  • June 29, 2026

  • 0 min

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Objective:

To illustrate the diagnostic challenges of identifying non-cardiac causes of chest pain in a patient with coronary artery disease.

Approach:
  • Case Presentation: A 65-year-old male presented with recurrent chest pain and underwent coronary stenting. Despite the procedure, his chest pain persisted, leading to further investigations that revealed acute pancreatitis and pancreatic cancer.
  • Diagnostic Assessment: Initial assessments focused on coronary artery disease, but subsequent evaluations revealed significant laboratory findings, including elevated CA19-9 levels, and imaging that indicated pancreatic issues.
Key Findings:
  • The patient had a history of acute pancreatitis and significant risk factors including smoking and alcohol use.
  • Coronary angiography revealed significant stenosis, leading to stenting, but chest pain persisted post-procedure.
  • Elevated CA19-9 levels were significant in the diagnostic process, indicating potential malignancy.
Interpretation:

The case highlights the necessity for clinicians to consider a broader differential diagnosis for persistent chest pain, especially in patients with complex medical histories.

Limitations:
  • This case is based on a single patient report, limiting generalizability.
  • Potential biases in clinical decision-making and diagnostic processes were not fully explored.
Conclusion:

This case underscores the importance of recognizing atypical presentations and the potential for serious underlying conditions when chest pain persists despite cardiac interventions.

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