Effects of SGLT2 inhibition on incident heart failure in carriers of cardiomyopathy-associated genetic variants - Summary - MDSpire

Effects of SGLT2 inhibition on incident heart failure in carriers of cardiomyopathy-associated genetic variants

  • By

  • Nicholas A. Marston

  • Shinwan Kany

  • Giorgio E. M. Melloni

  • Sean J. Jurgens

  • Frederick K. Kamanu

  • Yi-Pin Lai

  • Joel T. Rämö

  • Itamar Raz

  • Stephen D. Wiviott

  • Patrick T. Ellinor

  • Marc S. Sabatine

  • Christian T. Ruff

  • June 8, 2026

  • 0 min

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Objective:

To test the effect of the SGLT2 inhibitor dapagliflozin compared with placebo among carriers of CMP-associated genetic variants and noncarriers in the DECLARE-TIMI 58 trial.

Key Findings:
  • Carriers of CMP variants had a higher incidence of HHF (16%) compared to noncarriers (3.5%).
  • Dapagliflozin treatment resulted in an 82% reduction in HHF incidence among CMP variant carriers.
  • The absolute risk reduction for carriers was significantly greater (13.0%) than for noncarriers (1.0%).
  • The number needed to treat for carriers was 7.7 compared to 100 for noncarriers.
Interpretation:

Limitations:
  • The study primarily focused on a specific genetic subgroup, limiting generalizability.
  • Long-term effects and outcomes beyond the median follow-up of 4.2 years are not assessed.
Conclusion:

Original Source(s)

Effects of SGLT2 inhibition on incident heart failure in carriers of cardiomyopathy-associated genetic variants

  • by Nicholas A. Marston, Shinwan Kany, Giorgio E. M. Melloni, Sean J. Jurgens, Frederick K. Kamanu, Yi-Pin Lai, Joel T. Rämö, Itamar Raz, Stephen D. Wiviott, Patrick T. Ellinor, Marc S. Sabatine, Christian T. Ruff

  • June 8, 2026

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