Fatigue in Patients with Inflammatory Bowel Disease in Remission One Year After Diagnosis (the IBSEN III Study) - Summary - MDSpire

Fatigue in Patients with Inflammatory Bowel Disease in Remission One Year After Diagnosis (the IBSEN III Study)

  • By

  • Kristina A Holten

  • Tomm Bernklev

  • Randi Opheim

  • Bjørn C Olsen

  • Trond Espen Detlie

  • Vibeke Strande

  • Petr Ricanek

  • Raziye Boyar

  • May-Bente Bengtson

  • Tone B Aabrekk

  • Øyvind Asak

  • Svein Oskar Frigstad

  • Vendel A Kristensen

  • Milada Hagen

  • Magne Henriksen

  • Gert Huppertz-Hauss

  • Marte Lie Høivik

  • Lars-Petter Jelsness-Jørgensen

  • November 11, 2024

  • 0 min

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Objective:

To estimate the prevalence and likelihood of substantial and chronic fatigue in patients with Crohn’s disease (CD) and ulcerative colitis (UC) one year after diagnosis, based on different definitions of disease remission, specifically distinguishing between substantial fatigue (lasting ≥6 months) and chronic fatigue.

Key Findings:
  • Symptomatic remission significantly reduced the odds for substantial fatigue (SF) and chronic fatigue (CF) in both CD and UC.
  • Biochemical remission significantly reduced the odds for SF in UC.
  • Among patients in endoscopic/radiological remission, CF was associated with sleep disturbances and current treatment with infliximab.
  • Stricter definitions of disease remission did not correlate with decreased likelihood of fatigue.
Interpretation:

Fatigue remains prevalent in IBD patients even in remission, with specific factors like sleep disturbances and treatment influencing chronic fatigue levels, indicating a need for targeted interventions.

Limitations:
  • Study focused only on patients at one-year follow-up, limiting long-term insights.
  • Potential biases in self-reported fatigue assessments, as patients may underreport or overreport their fatigue levels.
Conclusion:

Fatigue in IBD patients persists despite remission, highlighting the need for comprehensive management strategies addressing fatigue beyond disease activity.

Original Source(s)

Fatigue in Patients with Inflammatory Bowel Disease in Remission One Year After Diagnosis (the IBSEN III Study)

  • by Kristina A Holten, Tomm Bernklev, Randi Opheim, Bjørn C Olsen, Trond Espen Detlie, Vibeke Strande, Petr Ricanek, Raziye Boyar, May-Bente Bengtson, Tone B Aabrekk, Øyvind Asak, Svein Oskar Frigstad, Vendel A Kristensen, Milada Hagen, Magne Henriksen, Gert Huppertz-Hauss, Marte Lie Høivik, Lars-Petter Jelsness-Jørgensen

  • November 11, 2024

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