Objective:

To enhance disease monitoring and pharmacovigilance during the rollout of the RTS,S/AS01E malaria vaccine in Ghana, Kenya, and Malawi, focusing on healthcare professionals' training and tool development.

Approach:

• Training and Tools: Tailored trainings and practical tools, including both paper-based and digital formats, were developed for healthcare professionals to improve knowledge and reporting of adverse events.
• Capacity Building: The initiative aimed to strengthen pharmacovigilance systems through active safety surveillance and predefined adverse events of interest.

Key Findings:

• Trainings were well received but faced challenges such as resource limitations and over-familiarity with materials.
• Limited uptake of newly introduced digital tools was noted.

Interpretation:

The strategies and challenges encountered during the RTS,S/AS01E rollout may inform future pharmacovigilance initiatives in similar contexts.

Limitations:

• Resource limitations affected training effectiveness.
• Over-familiarity with training materials may have reduced engagement.

Conclusion:

Insights gained from this initiative could support future capacity-building efforts in low- and middle-income countries for safer vaccine implementation.