Mapping Clinical Evidence from Randomized Controlled Trials on Acupuncture and Moxibustion for the Management of Dry Eye Disease - Summary - MDSpire

Mapping Clinical Evidence from Randomized Controlled Trials on Acupuncture and Moxibustion for the Management of Dry Eye Disease

  • By

  • Qidi Liu

  • Xiaobing Yang

  • Yanyan Hong

  • Tingting Wang

  • Sixuan Han

  • April 21, 2026

  • 0 min

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Objective:

To systematically integrate clinical evidence on acupuncture and moxibustion treatments for dry eye disease, aiming to provide reliable evidence-based support for clinical management.

Key Findings:
  • 319 studies included, with liver-kidney yin deficiency syndrome being the most common TCM syndrome (54.55%).
  • Identified 17 types of monotherapy and 31 types of combination therapy.
  • Outcome indicators were classified into 13 categories, with ocular surface health assessment, TCM symptom scores, and clinical efficacy being the most frequent.
Interpretation:

Acupuncture and moxibustion demonstrate potential benefits for dry eye disease, but existing RCTs exhibit low methodological quality, necessitating improvements.

Limitations:
  • Low methodological quality of included studies.
  • Need for standardized TCM syndrome differentiation and outcome indicators.
  • Low-quality studies may affect the reliability of findings.
Conclusion:

While acupuncture and moxibustion show promise in treating dry eye disease, improvements in RCT design and adherence to randomization are necessary for stronger evidence.

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