Development and Validation of a Novel Hepato-Metabolic-Renal Score Nomogram for Predicting Disease-Free Survival in Head and Neck Squamous Cell Carcinoma - Summary - MDSpire
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Development and Validation of a Novel Hepato-Metabolic-Renal Score Nomogram for Predicting Disease-Free Survival in Head and Neck Squamous Cell Carcinoma
To develop and validate an integrative physiological score for predicting disease-free survival (DFS) in surgical patients with head and neck squamous cell carcinoma (HNSCC).
Key Findings:
HMRS showed significant prognostic value for DFS in both training (HR=2.907, P=0.001) and validation (HR=2.356, P=0.031) cohorts.
The nomogram demonstrated excellent discrimination with AUCs of 0.913/0.899/0.896 in training and 0.952/0.891/0.923 in validation for 1/3/5 years.
Good calibration and positive net benefit were observed in decision curve analysis.
Subgroup analyses confirmed consistent performance across clinical subsets.
Interpretation:
The Hepato-Metabolic-Renal Score is a novel and practical tool for predicting recurrence risk in surgical HNSCC patients, enhancing personalized treatment strategies.
Limitations:
Single-center study may limit generalizability.
Further validation in diverse populations is needed.
Conclusion:
The HMRS and its nomogram represent a significant advancement in precision surgery for HNSCC, allowing for personalized recurrence risk estimation.
