MRI May Define Two Distinct Migraine Phenotypes
Patients with greater migraine burden showed widespread connectivity changes and lower cortical volume.
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By
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Andrea Surnit
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May 21, 2026
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Objective:
To investigate the potential of neuroimaging to separate migraine patients into distinct subgroups based on clinical and imaging profiles.
Key Findings:
- Ensure all findings are presented as stated in the source without additional interpretation.
Interpretation:
Remove the interpretation section.
Limitations:
- Modest sample size and cross-sectional design limited assessment of subgroup stability over time.
- Migraine phase during imaging and preventive medication use were not systematically recorded.
- The study was not designed to compare imaging-based subgrouping with clinical-only subgrouping approaches.
Conclusion:
The study applied a data-driven integration of functional and structural MRI features to characterize heterogeneity within migraine.
