MRI May Define Two Distinct Migraine Phenotypes
Patients with greater migraine burden showed widespread connectivity changes and lower cortical volume.
By
Andrea Surnit
May 21, 2026
Objective: To investigate the potential of neuroimaging to separate migraine patients into distinct subgroups based on clinical and imaging profiles.
Key Findings: Ensure all findings are presented as stated in the source without additional interpretation. Interpretation: Remove the interpretation section.
Limitations: Modest sample size and cross-sectional design limited assessment of subgroup stability over time. Migraine phase during imaging and preventive medication use were not systematically recorded. The study was not designed to compare imaging-based subgrouping with clinical-only subgrouping approaches. Conclusion: The study applied a data-driven integration of functional and structural MRI features to characterize heterogeneity within migraine.
