To integrate concepts in the immune cascade and explore immune cell interactions in atherosclerosis.
Approach:
Review of Literature: The review examines immune cell contributions and therapeutic strategies related to atherosclerosis.
Single-Cell Technologies: Utilizes single-cell RNA sequencing and spatial transcriptomics to reveal immune cell heterogeneity in atherosclerotic plaques.
Key Findings:
Atherosclerosis is a chronic inflammatory disease involving both innate and adaptive immunity.
Single-cell technologies have uncovered distinct immune cell subsets with varying roles in plaque development.
Clonal haematopoiesis links age-related mutations in hematopoietic stem cells to increased vascular inflammation.
Interpretation:
The review provides a comprehensive framework for understanding the immune mechanisms in atherosclerosis, integrating systemic factors and novel immune cell interactions.
Limitations:
The review may not cover all emerging research in the field of atherosclerosis.
Potential biases in the selection of studies may exist.
Conclusion:
The insights gained from this review could inform future therapeutic strategies targeting inflammatory pathways in atherosclerosis.
