To evaluate an 81-year-old man with high-grade urothelial carcinoma and complex medical history presenting with malaise, weakness, fatigue, and fever.
Approach:
Patient Background: An 81-year-old man with a history of high-grade urothelial carcinoma, chronic kidney disease, and other comorbidities presented after 5 months of malaise and 2 weeks of fever, following treatment with atezolizumab and tiragolumab.
Key Findings:
The patient had persistent fever despite antibiotic treatment.
Imaging revealed pulmonary nodules and mild pulmonary edema.
Laboratory tests indicated elevated troponin and renal dysfunction.
No infectious etiology was identified during hospitalization.
Interpretation:
The patient's symptoms and imaging findings raised concerns for possible infection, autoimmune conditions, or malignancy, but no definitive diagnosis was made.
Limitations:
The absence of a confirmed infectious source complicates diagnosis.
The patient's complex medical history complicates the interpretation of symptoms.
Conclusion:
The patient was discharged after 6 days without a clear diagnosis, continuing to experience malaise and weakness.
Standardized preprocessing, multicenter datasets, external validation, and interpretable models may matter more than further gains in classification accuracy
