Prevalence of CSF HIV VIRAL Escape and Associations With Neurocognitive Outcomes Among HIV-Associated Meningitis Survivors: A Cohort Study - Summary - MDSpire

Prevalence of CSF HIV VIRAL Escape and Associations With Neurocognitive Outcomes Among HIV-Associated Meningitis Survivors: A Cohort Study

  • By

  • Laura Nsangi

  • Gila Hale

  • Biyue Dai

  • Kathy Huppler Hullsiek

  • Asmus Tukundane

  • Alice Namudde

  • Grace B Menya

  • Peruth Ayebare

  • Lydia Nankungu

  • Olivie C Namuju

  • Susan Mulwana

  • Mable Kabahubya

  • David B Meya

  • David R Boulware

  • Fiona V Cresswell

  • Nathan C Bahr

  • Mahsa Abassi

  • Jayne Ellis

  • February 12, 2026

  • 0 min

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Objective:

To determine the prevalence of secondary CSF HIV viral escape and its association with neurocognitive outcomes in survivors of HIV-associated cryptococcal or tuberculous meningitis.

Key Findings:
  • Secondary CSF HIV viral escape occurred in 43% of participants, with a notable prevalence among ART-naïve individuals (68%).
  • Higher rates of neurocognitive impairment were observed in participants without CSF viral escape.
Interpretation:

Secondary CSF HIV viral escape is prevalent among survivors of HIV-associated meningitis and is associated with better neurocognitive outcomes, suggesting a complex relationship that may indicate a protective effect.

Limitations:
  • Small sample size may limit generalizability.
  • Cross-sectional nature of neurocognitive testing may not capture long-term outcomes.
  • Potential biases in participant selection or testing methods.
Conclusion:

The study highlights the complex relationship between CSF HIV viral escape and neurocognitive outcomes, warranting further investigation into its implications for treatment and management.

Original Source(s)

Prevalence of CSF HIV VIRAL Escape and Associations With Neurocognitive Outcomes Among HIV-Associated Meningitis Survivors: A Cohort Study

  • by Laura Nsangi, Gila Hale, Biyue Dai, Kathy Huppler Hullsiek, Asmus Tukundane, Alice Namudde, Grace B Menya, Peruth Ayebare, Lydia Nankungu, Olivie C Namuju, Susan Mulwana, Mable Kabahubya, David B Meya, David R Boulware, Fiona V Cresswell, Nathan C Bahr, Mahsa Abassi, Jayne Ellis

  • February 12, 2026

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