Linking a 10-Year Atherosclerotic Cardiovascular Disease Risk Score to New Cardiovascular Events in Stages 0–3 of Cardiovascular–Kidney–Metabolic Syndrome: Insights from the China Health and Retirement Longitudinal Study (CHARLS) - Summary - MDSpire
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Linking a 10-Year Atherosclerotic Cardiovascular Disease Risk Score to New Cardiovascular Events in Stages 0–3 of Cardiovascular–Kidney–Metabolic Syndrome: Insights from the China Health and Retirement Longitudinal Study (CHARLS)
To evaluate the association between baseline and cumulative ASCVD10 year scores and incident cardiovascular events across CKM syndrome stages 0–3 in a Chinese population.
Key Findings:
Baseline and cumulative ASCVD10 year scores are significantly associated with incident cardiovascular events.
Nonlinear associations between ASCVD risk and cardiovascular outcomes were identified.
Metabolic markers such as HbA1c and the TyG index mediated the relationship between ASCVD scores and cardiovascular events.
Interpretation:
The study highlights the importance of ASCVD risk scores in predicting cardiovascular events in the context of CKM syndrome, emphasizing the need for targeted interventions in high-risk populations.
Limitations:
Exclusion of participants with pre-existing cardiovascular conditions may limit generalizability.
Reliance on self-reported data could introduce bias.
The study's observational nature limits causal inferences.
Conclusion:
The findings underscore the utility of ASCVD10 year scores in identifying individuals at risk for cardiovascular events, supporting the need for early intervention strategies in populations with CKM syndrome.
