CD4/CD8 ratio is associated with structural reorganization of vaccine-induced immune responses in people living with HIV - Summary - MDSpire

CD4/CD8 ratio is associated with structural reorganization of vaccine-induced immune responses in people living with HIV

  • By

  • Faith Jessica Paran

  • Mizue Saita

  • Rieko Oyama

  • Namiko Nomura

  • Kaori Saito

  • Abdullah Khasawneh

  • Pei Gao

  • Songling Li

  • Hendra Saputra Ismanto

  • Noriyo Nagata

  • Naoko Iwata

  • Yasushi Okazaki

  • Tadaki Suzuki

  • Yuki Uehara

  • Kazuhisa Takahashi

  • Daron M Standley

  • Yoko Tabe

  • Toshio Naito

  • June 1, 2026

  • 0 min

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Objective:

To investigate how the CD4/CD8 ratio influences vaccine-induced immune responses in people living with HIV (PLWH).

Key Findings:
  • Distinct immune states were observed in PLWH based on CD4/CD8 ratio.
  • Normal CD4/CD8 ratios showed focused transcriptional activation, while low ratios exhibited broad transcriptional dysregulation.
  • Low CD4/CD8 ratio group had increased monocyte-specific node degree in PPI networks, indicating altered immune coordination.
  • Clonal skewing and reduced clonotype diversity were noted in the low CD4/CD8 ratio group.
Interpretation:

Remove unsupported conclusions about immune coordination and response dynamics.

Limitations:
  • Small sample size of participants limits generalizability.
  • Study focused on a specific vaccination type (mRNA vaccines) and may not apply to other vaccine platforms.
Conclusion:

Revise to eliminate unsupported claims about the importance of the CD4/CD8 ratio.

Original Source(s)

CD4/CD8 ratio is associated with structural reorganization of vaccine-induced immune responses in people living with HIV

  • by Faith Jessica Paran, Mizue Saita, Rieko Oyama, Namiko Nomura, Kaori Saito, Abdullah Khasawneh, Pei Gao, Songling Li, Hendra Saputra Ismanto, Noriyo Nagata, Naoko Iwata, Yasushi Okazaki, Tadaki Suzuki, Yuki Uehara, Kazuhisa Takahashi, Daron M Standley, Yoko Tabe, Toshio Naito

  • June 1, 2026

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