Association between red blood cell transfusion and adverse clinical outcomes is Independent of cardiac history: a multicenter observational InPUT study analysis - Summary - MDSpire

Association between red blood cell transfusion and adverse clinical outcomes is Independent of cardiac history: a multicenter observational InPUT study analysis

  • By

  • Antoine Kimmoun

  • Nicolas Girerd

  • Kevin Duarte

  • Jolie Bruno

  • Jimmy Schenk

  • Bruno Levy

  • Guillaume Baudry

  • Senta Jorinde Raasveld

  • Sanne de Bruin

  • Merijn C. Reuland

  • Claudia van den Oord

  • Caroline M. Schaap

  • Jan Bakker

  • Maurizio Cecconi

  • Aarne Feldheiser

  • Jens Meier

  • Zoe McQuilten

  • Marcella C. A. Müller

  • Thomas W. L. Scheeren

  • Cécile Aubron

  • Andrew W. J. Flint

  • Tarikul Hamid

  • Michaël Piagnerelli

  • Tina Tomić Mahečić

  • Jan Benes

  • Lene Russell

  • Hernan Aguirre-Bermeo

  • Konstantina Triantafyllopoulou

  • Vasiliki Chantziara

  • Mohan Gurjar

  • Sheila Nainan Myatra

  • Vincenzo Pota

  • Muhammed Elhadi

  • Ryszard Gawda

  • Mafalda Mourisco

  • Marcus Lance

  • Vojislava Neskovic

  • Matej Podbregar

  • Juan V. Llau

  • Manual Quintana-Diaz

  • Maria Cronhjort

  • Carmen A. Pfortmueller

  • Nihan Yapici

  • Nathan Nielsen

  • Akshay Shah

  • Harm-Jan de Grooth

  • Alexander P. J. Vlaar

  • Alexandre Mebazaa

  • December 18, 2025

  • 0 min

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Objective:

To investigate the impact of red blood cell (RBC) transfusion on clinical outcomes, specifically death, acute kidney injury (AKI), and ventilatory weaning failure (VWF), in critically ill patients with and without cardiac history.

Key Findings:
  • No significant difference in the composite outcome of death, AKI, or VWF between patients with and without cardiac history after RBC transfusion, suggesting similar risks.
  • Adherence to restrictive transfusion strategies remains low, particularly in patients with cardiac history, indicating a need for improved compliance.
  • Anaemia is prevalent in critically ill patients, affecting up to 90% during their ICU stay, highlighting the importance of monitoring and managing haemoglobin levels.
Interpretation:

RBC transfusion does not appear to influence clinical outcomes differently in patients with a cardiac history compared to those without, supporting the use of restrictive transfusion strategies to optimize patient care.

Limitations:
  • Observational design may limit causal inferences, necessitating cautious interpretation of results.
  • Variability in clinical practice and definitions of cardiac history across centers may affect the generalizability of findings.
Conclusion:

RBC transfusion practices should adhere to restrictive strategies regardless of cardiac history, as outcomes do not significantly differ based on this factor, emphasizing the need for standardized transfusion protocols.

Original Source(s)

Association between red blood cell transfusion and adverse clinical outcomes is Independent of cardiac history: a multicenter observational InPUT study analysis

  • by Antoine Kimmoun, Nicolas Girerd, Kevin Duarte, Jolie Bruno, Jimmy Schenk, Bruno Levy, Guillaume Baudry, Senta Jorinde Raasveld, Sanne de Bruin, Merijn C. Reuland, Claudia van den Oord, Caroline M. Schaap, Jan Bakker, Maurizio Cecconi, Aarne Feldheiser, Jens Meier, Zoe McQuilten, Marcella C. A. Müller, Thomas W. L. Scheeren, Cécile Aubron, Andrew W. J. Flint, Tarikul Hamid, Michaël Piagnerelli, Tina Tomić Mahečić, Jan Benes, Lene Russell, Hernan Aguirre-Bermeo, Konstantina Triantafyllopoulou, Vasiliki Chantziara, Mohan Gurjar, Sheila Nainan Myatra, Vincenzo Pota, Muhammed Elhadi, Ryszard Gawda, Mafalda Mourisco, Marcus Lance, Vojislava Neskovic, Matej Podbregar, Juan V. Llau, Manual Quintana-Diaz, Maria Cronhjort, Carmen A. Pfortmueller, Nihan Yapici, Nathan Nielsen, Akshay Shah, Harm-Jan de Grooth, Alexander P. J. Vlaar, Alexandre Mebazaa

  • December 18, 2025

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