Objective:

To evaluate the reporting of geographic, socioeconomic, and core demographic variables in primary randomized cancer clinical trial reports.

Approach:

Key Findings:

• Patients from rural areas experience worse cancer outcomes due to limited access to care.
• Area-level socioeconomic deprivation correlates with poorer cancer survival rates.
• Reporting of geographic and socioeconomic factors in clinical trials is often inadequate.

Interpretation:

The review highlights the need for improved representation of geographic and socioeconomic factors in cancer clinical trials to enhance the generalizability of findings.

Limitations:

• The review was not prospectively registered and lacked a formal protocol.
• It was designed as a descriptive review rather than a meta-analysis.

Conclusion:

Improving the reporting of geographic and socioeconomic variables in cancer trials is essential for understanding treatment effects across diverse populations.

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