Comparative assessment of tissue cross-reactivity and pharmacokinetic half-life of malaria monoclonal antibodies - Summary - MDSpire

Comparative assessment of tissue cross-reactivity and pharmacokinetic half-life of malaria monoclonal antibodies

  • By

  • William R. Fugina

  • Dallas R. Brown

  • Shelby Foor

  • Emma C. Ryan

  • Samuel Cuevas

  • Shreeram Nallar

  • Dawn Wolf

  • Renita Brown

  • Jesse P. Deluca

  • Geoffrey C. Chin

  • Elizabeth J. Raymond

  • James T. Raymond

  • Phil S. Medlin

  • Sheetij Dutta

  • June 23, 2026

  • 0 min

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Objective:

To optimize human tissue cross-reactivity and half-life extension methods for monoclonal antibodies targeting Plasmodium falciparum circumsporozoite protein.

Approach:
    Key Findings:
    • TCR assay showed no membrane binding; mAbs 317 and 311 had varying positive cross-reactivity to extracellular and cytoplasmic elements.
    • CIS43 showed no TCR positivity.
    • MAb 311-LS exhibited improved binding affinity to FcRn and a better pharmacokinetic profile compared to wild-type 311.
    Interpretation:

    The findings emphasize the importance of early evaluation of TCR liabilities in mAb development and demonstrate the efficacy of HLE strategies in improving mAb longevity.

    Limitations:
    • Study limited to prototype mAbs and specific tissue types.
    • Results may not fully predict human responses.
    Conclusion:

    The study provides benchmarks for developing long-acting anti-malarial mAbs.

Original Source(s)

Comparative assessment of tissue cross-reactivity and pharmacokinetic half-life of malaria monoclonal antibodies

  • by William R. Fugina, Dallas R. Brown, Shelby Foor, Emma C. Ryan, Samuel Cuevas, Shreeram Nallar, Dawn Wolf, Renita Brown, Jesse P. Deluca, Geoffrey C. Chin, Elizabeth J. Raymond, James T. Raymond, Phil S. Medlin, Sheetij Dutta

  • June 23, 2026

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