To systematically review and analyze the association between the triglyceride-glucose (TyG) index and the risk of diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes mellitus (T2DM).
Approach:
Systematic Review and Meta-Analysis: A systematic review and meta-analysis were conducted by searching multiple databases for observational studies that examined the association of the TyG index with DPN risk among T2DM patients. Data extraction and quality assessment were performed independently…
Key Findings:
Fourteen studies with 32,281 participants were included in the analysis.
Higher TyG index values were associated with increased DPN risk, with a pooled odds ratio (OR) of 2.614 (95% CI: 1.788-3.821, P < 0.0001) and a pooled hazard ratio (HR) of 1.248 (95% CI: 1.003-1.553, P = 0.0471).
The association was consistent across most subgroups defined by age, sample size, BMI, and adjustment for confounding factors.
Statistical significance was not achieved for the association in the non-China subgroup.
Interpretation:
Higher TyG values correlate with greater DPN risk among T2DM patients.
Limitations:
The relationship between TyG index and DPN risk may not be causal without further validation.
Inconsistencies in findings across different geographical subgroups.
Conclusion:
The findings may inform clinical screening of DPN risk in T2DM patients.
Women reported improvement across 6 cognitive domains during 12 months of estriol-based treatment, while murine models suggested a potential astrocyte-mediated mechanism.
