Weight Loss, Comorbidity, and Complications After Single-anastomosis Sleeve Ileal Bypass (SASI): A Systematic Review and Meta-analysis - Summary - MDSpire

Weight Loss, Comorbidity, and Complications After Single-anastomosis Sleeve Ileal Bypass (SASI): A Systematic Review and Meta-analysis

  • By

  • Helene Marie Haug

  • Hilde Risstad

  • Rolf Eikeland Hagen

  • Tom Mala

  • Jon Adalsteinn Kristinsson

  • Torgeir Thorson Søvik

  • June 24, 2026

  • 0 min

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Objective:

To update the evidence base on the relative effect of single-anastomosis sleeve ileal bypass (SASI) compared to other bariatric procedures regarding weight reduction, remission of type 2 diabetes (T2DM), remission of dyslipidemia, nutritional status, and complications, while assessing the certainty of evidence using the GRADE approach.

Approach:
  • Eligibility Criteria: Included studies were RCTs or NRCTs evaluating SASI with other bariatric procedures, with a minimum follow-up of 1 year, focusing on weight loss and metabolic outcomes.
Key Findings:
  • SASI shows potential for substantial weight loss and metabolic improvements.
  • Concerns remain regarding the risk of protein-calorie malnutrition and long-term effects.
  • Previous systematic reviews lacked assessments of evidence quality.
Interpretation:

Initial studies indicate that SASI may offer outcomes comparable to established bariatric procedures, but further evaluation is necessary due to concerns about nutritional deficiencies.

Limitations:
  • Limited number of studies available for analysis.
  • Previous reviews did not assess evidence quality.
Conclusion:

Further research is warranted to fully understand the long-term effects and safety of SASI.

Sources:

Original Source(s)

Weight Loss, Comorbidity, and Complications After Single-anastomosis Sleeve Ileal Bypass (SASI): A Systematic Review and Meta-analysis

  • by Helene Marie Haug, Hilde Risstad, Rolf Eikeland Hagen, Tom Mala, Jon Adalsteinn Kristinsson, Torgeir Thorson Søvik

  • June 24, 2026

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