Placental expression and activity of system A and system L amino acid transporters in pregnancies complicated by diabetes mellitus and fetal growth disorders: a systematic review - Summary - MDSpire
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Placental expression and activity of system A and system L amino acid transporters in pregnancies complicated by diabetes mellitus and fetal growth disorders: a systematic review
To systematically evaluate the expression levels and functional activity of System A and System L amino acid transporters in placentas from pregnancies complicated by diabetes mellitus and fetal growth disorders.
Approach:
Systematic Review Methodology: Seventeen studies were selected for data extraction in accordance with PRISMA guidelines.
Key Findings:
Pregnancies with fetal growth restriction (FGR) or small-for-gestational age (SGA) fetuses show significant downregulation of System A and L activity and reduced expression of placental isoforms (SNAT1, SNAT2, LAT1).
Pregnancies complicated by diabetes mellitus exhibit upregulated transport capacity, correlated with increased placental mass and expression of SNAT1 and LAT1 isoforms.
Time-dependent variations in transporter expression were noted, particularly the downregulation of SNAT4 in early-onset FGR.
Interpretation:
Limitations:
The causal relationship between placental transport capacity alterations and fetal growth abnormalities remains to be determined.
The review is limited to studies available in selected databases and may not encompass all relevant research.
Single-nucleus sequencing of menstrual fluid identified epithelial gene signatures and prioritized five candidate biomarkers that warrant validation in larger studies.
