To explore the mechanisms by which TSH promotes thyroid cancer progression and to develop an individualized decision-making framework for TSH suppression therapy.
Approach:
Mechanistic Review: Details the regulatory mechanisms by which TSH promotes thyroid cancer cell proliferation, invasion, and dedifferentiation.
Individualized Decision-Making Framework: Develops a framework based on patient factors, tumor traits, and treatment processes to guide TSH suppression therapy.
Key Findings:
TSH plays a significant pro-tumorigenic role in thyroid cancer progression.
Individualized TSH suppression therapy is necessary due to variability in patient responses and treatment tolerances.
The latest ATA guidelines recommend assessing recurrence risk based on tumor characteristics and individualizing TSH suppression.
Interpretation:
Limitations:
Challenges in implementing individualized therapy due to physiological and biological differences among patients.
Complexity in clinical decision-making arising from varying patient needs and treatment goals.
Conclusion:
The review aims to transition postoperative management of differentiated thyroid cancer from empirical treatment to individualized precision medicine.
