Trained immunity as a systemic bridge: the liver-gut-immune-oral axis in the comorbidity of chronic liver disease and periodontitis - Summary - MDSpire
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Trained immunity as a systemic bridge: the liver-gut-immune-oral axis in the comorbidity of chronic liver disease and periodontitis
To examine the role of trained immunity (TI) in chronic liver diseases and periodontitis, linking these comorbidities through the 'Liver-Gut-Immune-Oral Axis.'
Key Findings:
Trained immunity allows innate immune cells to acquire long-term functional memory through metabolic and epigenetic reprogramming.
Chronic liver diseases and periodontitis coexist and may exacerbate each other, as suggested by current evidence.
Both conditions share metabolic-epigenetic reprogramming circuits.
Interpretation:
Limitations:
The pathways are inferred from separate bodies of literature rather than multimodal cohort studies, highlighting the need for empirical validation.
The relative contribution of trained immunity versus other mechanisms varies by disease stage and etiology, as noted in the literature.
