Initiation of an emergency department discharge pathway for low-risk patients with venous thromboembolism: Factors impact real-world practice - Summary - MDSpire

Initiation of an emergency department discharge pathway for low-risk patients with venous thromboembolism: Factors impact real-world practice

  • By

  • William B Stubblefield

  • James Barclay

  • Jesse O Wrenn

  • Doug Conway

  • Scott Nelson

  • Quinn S Wells

  • Dario Giuse

  • Zhao Zuo

  • Alexandra M Baird

  • Tyler Barrett

  • Shi Huang

  • Karen Beauchamp

  • Alan B Storrow

  • Sean P Collins

  • Joshua A Beckman

  • July 6, 2026

  • 0 min

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Objective:

To evaluate the effect of a discharge pathway for low-risk VTE patients on patient outcomes in the emergency department.

Approach:
  • Study Design: A retrospective cohort study of 1260 patients with VTE diagnosed in the ED, comparing data from two years before and after the implementation of a discharge pathway.
  • Pathway Implementation: The pathway included an outpatient VTE guidance document, scheduling follow-ups, and DOAC prescriptions facilitated by clinical pharmacists.
  • Data Collection: Patient demographics, medical history, labs, medications, and outcomes were extracted using an NLP algorithm and various coding systems.
Key Findings:
  • The incidence of VTE has increased significantly in the US and Europe over the last two decades.
  • Only 1 in 13 eligible patients with PE are treated at home, indicating a gap in outpatient management.
  • Approximately 30-50% of patients with PE may be low risk and suitable for discharge.
Interpretation:

The study evaluates the implementation of a discharge protocol for low-risk VTE patients.

Limitations:
  • Individual pathway use could not be measured retrospectively, which limits understanding of its practical application.
  • The study was not designed as a formal quality improvement intervention.
Conclusion:

The implementation of a discharge protocol for low-risk VTE patients may enhance outpatient management.

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