Reduced left dorsolateral prefrontal activation and right inferior frontal de-oxygenation differ between psychotic and non−psychotic adolescent depression during verbal fluency - Summary - MDSpire
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Reduced left dorsolateral prefrontal activation and right inferior frontal de-oxygenation differ between psychotic and non−psychotic adolescent depression during verbal fluency
To investigate whether prefrontal hemodynamic responses during cognitive challenges differ between adolescents with major depressive disorder with psychotic symptoms (MDD-Psy) and those without (MDD-NonPsy).
Key Findings:
MDD-Psy adolescents had higher KDAS and BPRS scores compared to MDD-NonPsy (p < 0.001).
MDD-NonPsy showed positive deviations in specific channels, while MDD-Psy exhibited negative deviations in the left middle frontal gyrus (pFDR = 0.004).
Only the right inferior frontal gyrus showed significant differences in deoxygenated hemoglobin (HbR) between groups (pFDR = 0.030).
ROC analyses indicated modest classification accuracy for psychosis (AUC = 0.577-0.581, p = 0.030).
Interpretation:
Limitations:
The absence of healthy control or other psychiatric comparison groups limits the ability to establish diagnostic specificity.
Findings require replication in independent samples.
