Objective:

To present a case of refractory hypokalemia in a patient with Sjögren’s disease and Gitelman syndrome.

Approach:

Key Findings:

• The patient had severe hypokalemia disproportionate to Sjögren’s disease alone.
• Genetic analysis confirmed compound heterozygous mutations in SLC12A3, indicating Gitelman syndrome.
• Symptoms resolved and potassium levels stabilized with combined therapy.

Interpretation:

Limitations:

• The case is based on a single patient, limiting generalizability.
• Further studies are needed to establish broader diagnostic protocols.

Conclusion:

Accurate diagnosis of comorbidities in Sjögren’s disease requires combining immunological evaluation with genetic testing.

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